59. Lin J-C, Hsu C-Y, Chen J-Y, Fang Z-S, Chen H-W, Yao B-Y, Shiau GHM, Tsai J-S, Gu M, Jung M, Lee T-Y, Hu C-M* Facile transformation of murine and human primary dendritic cells into robust and modular artificial antigen-presenting systems by intracellular hydrogelation. Advanced Materials, 2021, in press. 


58. Yang K-C, Lin J-C, Tsai H-H, Hsu C-Y, Shih V, Hu C-M* Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Delivery and Translational Research, 2021, in press. 


57. Lin P-H, Liang C-Y, Yao B-Y, Chen H-W, Pan C-F, Wu L-L, Lin Y-H, Hsu Y-S, Liu Y-H, Chen P-J, Hu C-M*, Yang H-C* Robust induction of resident memory T cells by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses. Molecular Therapy-Methods and Clinical Development, 2021, in press. 




56. Chattopadhyay S, Hu C-M* Nanomedicinal delivery of STING agonists: recent advances in virus vaccination. Nanomedicine, 2020, 15(29):2883-2894. [Link].

55. Huang P-H, Tsai H-H, Liao P-H, Lin Y-H, Chou Y-C, Hu C-M, Chen H-W* Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain. Human Vaccines and Immunotherapeutics, 2020, Sep 29; 1-2. [Link].

54. Lin S-Y, Yao B-Y, Hu C-M, Chen H-W*. Induction of robust immune responses by CpG-ODN loaded hollow polymeric nanoparticles for antiviral and vaccine applications in chickens. International Journal of Nanomedicine, 2020, 15, 3303-3318. [Link].

53. Chattopadhyay S, Liu Y-H, Fang Z-S, Lin C-L, Lin J-C, Yao B-Y, Hu C-M*. Synthetic immunogenic cell death mediated by intracellular delivery of STING agonist nanoshells enhances anti-cancer chemo-immunotherapy. Nano Letters, 2020, 20, 4, 2246-2256 [Link]. 


52. Lin C-W, Huang C-Y, Yao B-Y, Lin J-C, Agrawal A, Algaissi A, Peng B-H, Liu Y-H, Huang P-H, Juang R-H, Chang Y-C, Tseng C-T, Chen H-W, Hu C-M*. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against Middle East respiratory syndrome coronavirus. Advanced Functional Materials, 2019, 1087616 [Link]. 

Press Release [Link][Link][Link]

51. Lin J-C, Chien C-Y, Lin C-L, Yao B-Y, Chen Y-I, Liu Y-H, Fang Z-S, Chen J-Y, Chen W-Y, Lee N-N, Chen H-W, Hu C-M*Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nature Communications, 2019, 10: 1057. [Link]

Press Release [Link]


50. Hu C-M, Chen Y-T, Fang Z-S, Chang W-S, Chen H-W. Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection. International Journal of Nanomedicine, 2018, 13:8579-8593. [Link]

49. Liu Y-H, Kuo S-C, Yao B-Y, Fang Z-S, Lee Y-T, Chang Y-C, Chen T-L, Hu C-M*. Colistin Nanoparticle Assembly by Coacervate Complexation with Polyanionic Peptides for Treating Drug-Resistant Gram-Negative Bacteria. Acta Biomaterialia, 2018, 82:133-142. [Link]


48. Luk B, Jiang Y, Copp J, Hu C-M, Krishnan N, Gao W, Li S, Fang R, Zhang L. Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions. Molecular Pharmaceutics, 2018, 15(9): 3723-3728. [Link]

47. Lin C-W, Chattopadhyay S, Lin J-C, Hu C-M*. Advances and opportunities in nanoparticle and nanomaterial-based vaccines against bacterial infections. Advanced Healthcare Materials, 2018, 7(13):e1701395. [Link]


46. Chen H-W, Fang Z-S, Chen Y-T, Chen Y-I, Yao B-Y, Cheng J-Y, Chien G-Y, Chang Y-C, Hu C-M*. Targeting and enrichment of viral pathogen by cell membrane cloaked magnetic nanoparticles for enhanced detection. ACS Applied Materials & Interfaces, 2017, 9(46): 39953-39961. [Link]

Highlighted: Science News [Link]

45. Hu C-M, Chang WS, Fang ZS, Chen YT, Wang WL, Tsai HH, Chueh LL, Takano T, Hohdatsu T, HW Chen. Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus. Scientific Reports, 2017, 7: 13043. [Link]  

44. Chattopadhyay S, Chen JY, Chen HW, Hu C-M*. Nanoparticle vaccines adopting virus-like features for enhanced immune potentiation. Nanotheranostics, 2017, 1(3): 233-260. [Link]

43. Hu C-M, Chien CY, Liu MT, Fang ZS, Chang SY, Juang RH, Chang SC, Chen HW. Multi-antigen avian influenza A (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. BMC Biotechnology, 2017, 17:2. [Link]  


42. Lin SY, Li YT, Chen YT, Chen TC, Hu C-M, Chen HW. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. Scientific Reports, 6, 37725, 2016. [Link]

41. Cheng B, Toh EK, Chen KH, Chang YC, Hu C-M, Wu HC, Chau LY, Chen P, Hsieh PC. Biomimicking platelet-monocyte interactions as a novel targeting strategy for heart healing. Advanced Healthcare Materials, 4, 2686-2697, 2016. [Link]

40. Chen H-W, Huang C-Y, Lin S-Y, Fang Z-S, Hsu C-H, Lin J-C, Chen Y-I, Yao B-Y, Hu C-M*. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials, 106, 111-118, 2016. [Link]

39. Dehaini D, Fang R, Luk B, Pang Z, Hu C-M, Kroll A, Yu CL, Gao W, Zhang L. Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery. Nanoscale, 8, 14411-14419, 2016. [Link]

38. Luk B, Fang R, Hu C-M, Copp J, Thamphiwatana S, Dehaini D, Gao W, Zhang K, Li S, Zhang L. Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors. Theranostics, 6, 1004-1011, 2016. [Link]


37. Wang F, Fang R, Luk B, Hu C-M, Thamphiwatana S, Dehaini D, Angsantikul P, Kroll A, Pang Z, Gao W, Lu W, Zhang L. Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection. Advanced Functional Materials, 26, 1628-1635, 2016. [Link]



36. Hu C-M, Fang RH, Wang K-C, Luk BT, Thamphiwatana SK, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel S, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Nanoparticle biointerfacing by platelet membrane cloaking. Nature, 526, 118-121, 2015. [Link]

Highlighted: Nature 2015, 526, 47-48 (News & Views). [Link
                   Nature News September 16, 2015. [Link]
                   Science Translational Medicine 2015, 7 (307), 307ec169. [Link


35. Pang Z, Hu C-M, Fang R, Luk B, Gao W, Zhang L. Detoxification of organophosphate poisoning using nanoparticle bioscavengers. ACS Nano, 9, 6450-6458, 2015. [Link]


34. Fang R, Luk B, Hu C-M*, Zhang L*. Engineered nanoparticles mimicking cell membranes for toxin neutralization. Advanced Drug Delivery Reviews, 90, 69-80, 2015. *Co-corresponding author. [Link][Jounal Cover]


33. Wang F, Gao W, Thamphiwatana S, Luk B, Angsantikul P, Zhang Q, Hu C-M, Fang R, Copp J, Pornpattananangkul, Lu W, Zhang L. Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection. Advanced Materials, 27, 3431-3443, 2015. [Link]


32. Gao W, Fang R, Thamphiwatana S, Luk B, Li J, Angsantikul P, Zhang Q, Hu C-M, Zhang L. Modulating antibacterial immunity via bacterial membrane-coated nanoparticles. Nano Letters, 15, 1403-1409, 2015. [Link]



31. Copp J, Fang R, Luk B, Hu C-M, Gao W, Zhang K, Zhang L. Clearance of pathologic antibodies using biomimetic nanoparticles. Proceedings of the National Academy of Sciences, 111, 13481-13486, 2014. [Link]


30. Hu C-M, Zhang L. Nanotoxoid Vaccines. Nano Today, 9, 401-404, 2014. [Link]


29. Fang RH, Hu C-M, Luk B, Gao W, Copp J, Tai Y, O'Connor D, Zhang L. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Letters, 14, 2181-2188, 2014. [Link]


28. Hu C-M, Fang RH, Luk B, Zhang L. Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies. Nanoscale, 6, 65-75, 2014. [Link]


27. Luk B*, Hu C-M*, Fang RH, Dehaini D, Carpenter C, Gao W, Zhang L. Interfacial interactions between natural RBC membranes and synthetic polymeric particles. Nanoscale, 6, 2730-2737, 2014. [Link] *The authors contributed equally.



26. Hu C-M, Fang RH, Luk B, Zhang L. Nanoparticle-detained toxin for safe and effective vaccination. Nature Nanotechnology, 8, 933-938, 2013. [Link]

                              Highlighted: Science 2013, 342, 1418. [Link]                             

                              NIH Director's Blog, December 12, 2013. [Link]                             

                              MIT Technology Review, January 3, 2014. [Link]


25. Gao W, Hu C-M, Fang RH, Zhang L. Liposome-like nanostructures for drug delivery. Journal of Materials Chemistry B, 1, 6569-6585, 2013. [Link]


24. Hu C-M, Fang RH, Copp J, Luk B, Zhang L. A biomimetic toxin nanosponge that absorbs pore-forming toxins. Nature Nanotechnology, 8, 336-340, 2013. [Link]

                               Highlighted: Science Translational Medicine 2013, 5 (184), 184ec78. [Link]                             

                               Nano Today, 2013, 8, 217-218. (News and Opinions) [Link]                             

                               MIT Technology Review, April 14, 2013. [Link]


23. Fang RH, Hu C-M, Chen K, Luk B, Carpenter C, Gao W, Li S, Zhang D-E, Lu W, Zhang L. Lipid-insertion enables targeting functionalization of erythocyte membrane-cloaked nanoparticles. Nanoscale, 5, 8884-8888, 2013. [Link]


22. Gao W, Hu C-M, Fang RH, Luk B, Su J, Zhang L. Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes. Advanced Materials, 25, 3549-3553, 2013. [Link]


21. Hu C-M, Fang RH, Luk B, Chen K, Carpenter C, Gao W, Zhang K, Zhang L. ‘Marker-of-self’ functionalizaton of nanoscale particles through a top-down cellular membrane coating approach. Nanoscale, 5, 2664-2668, 2013. [Link]

                  Selected as HOT article of the week by Nanoscale.


20. Kong S, Sartor M, Hu C-M, Zhang W, Zhang L, Jin S. Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release. Acta Biomaterialia, 9, 5447-5452, 2013. [Link]


19. Aryal S, Hu C-M, Fang RH, Dehaini D, Carpenter C, Zhang D-E, Zhang L. Erythrocyte membrane- cloaked polymeric nanoparticles for controlled drug loading and release. Nanomedicine, 8, 1271-1280, 2013. [Link]



18. Hu C-M, Fang RH, Zhang L. Erythrocyte-inspired delivery systems. Advanced Healthcare Materials, 1, 537-547, 2012. [Link]


17. Fang RH, Chen K, Aryal S, Hu C-M, Zhang K, Zhang L. Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor. Langmuir, 28, 13824-13829, 2012. [Link]


16. Hu C-M, Zhang L. Nanoparticle-based combination therapy to overcome drug resistance in cancer. Biochemical Pharmacology, 83, 1104-1111, 2012. [Link]


15. Aryal S, Hu C-M, Zhang L. Synthesis of Ptsome: A platinum-based liposome-like nanostructure. Chemical Communications, 48, 2630-2632, 2012. [Link]


14. Fang, RH, Hu C-M, Zhang L. Nanoparticles disguised as red blood cells to evade the immune system. Expert Opinion on Biological Therapy, 12, 385-389, 2012. [Link]


13. Aryal S, Hu C-M, Zhang L. Nanoparticle drug delivery enhances the cytotoxicity of hydrophobic-hydrophilic drug conjugates. Journal of Materials Chemistry, 22, 994-999, 2012. [Link]



12. Hu C-M, Zhang L, Aryal S, Cheung C, Fang R, Zhang L. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proceedings of the National Academy of Sciences​, 10980-10985, 2011. [Link]

Highlighted: Nano Today 2011, 6, 327. (News and Opinions) [Link]                           


11. Aryal S, Hu C-M, Zhang L. Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy. Molecular Pharmaceutics, 8, 1401-1407, 2011. [Link]


10. Balasubramanian S, Kagan D, Hu C-M, Campuzano S, Lobo-Castañon M, Lim N, Kang D, Zhang L, Wang J. Micromachine enabled capture and isolation of cancer cells in complex media. Angewandte Chemie International Edition, 50, 4161-4164, 2011. [Link]



9.  Hu C-M, Kaushal S, Cao HS, Aryal S, Sartor M, Esener S, Bouvet M, Zhang L. Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen (CEA) presenting pancreatic cancer cells. Molecular Pharmaceutics, 7, 914-920, 2010. [Link]


8.  Fang R, Aryal S, Hu C-M, Zhang L. Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method. Langmuir, 26, 16958-16962, 2010. [Link]


7.  Hu C-M, Aryal S, Zhang L. Nanoparticles assisted combination therapies for effective cancer treatment. Therapeutic Delivery, 1, 323-334, 2010. [Link]


6.  Zhang L, Pornpattananangkul D, Hu C-M, Huang C-M. Development of nanoparticles for antimicrobial drug delivery. Current Medicinal Chemistry, 17, 585-594, 2010. [Link]


5.  Aryal S, Hu C-M, Zhang L. Combinatorial drug conjugation enabled nanoparticle dual drug delivery. Small, 6, 1442-1448, 2010. [Link]

Before 2009

4.  Aryal S, Hu C-M, Zhang L, Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery. ACS Nano, 4, 251-258, 2009. [Link]

3.  Hu C-M, Zhang L. Therapeutic nanoparticles to combat cancer drug resistance. Current Drug Metabolism, 10, 836-841, 2009. [Link]


2.  Lefkowitz RB, Marciniak JY, Hu C-M, Schmid-Schönbein GW, Heller MJ. An electrophoretic method for the detection of chymotrypsin and trypsin activity directly in whole blood. Electrophoresis, 31, 403-410, 2009. [Link]


1.  Stoeber B, Hu C-M, Liepmann D, Muller SJ. Passive flow control in microdevices using thermally responsive polymer solutions. Physics of Fluids, 18, 053103, 2006. [Link]

© 2015 by Hu Research Group of Institute of Biomedical Sciences, Academia Sinica